MOUSE CLINIC FOR CANCER AND AGING

The aging population in developed countries leads to rapid increase in cancer incidence and other aging-related disorders. To accelerate cancer and aging research and to contribute to the theme of ‘healthy aging’, the Netherlands Cancer Institute (NKI) and the European Research Institute for the Biology of Aging (ERIBA) have established a Mouse Clinic for Cancer and Aging research (MCCA). The MCCA aims to accelerate the development of genetically engineered mouse models (GEMMs) of human cancer and aging syndromes. These mouse models will be used for developing new therapies against cancer and aging-related diseases.

The MCCA houses four key expertises

A Transgenic facility for the generation of genetically modified mouse strains on either wildtype or complex genetic backgrounds.

A Mouse Cancer Clinic for preclinical intervention studies to determine therapy responses in advanced mouse models of human cancer.

An Aging and Phenotyping Facility for controlled aging and phenotyping studies in different inbred mouse strains and GEMMs, combined with a centralized biobank of frozen mouse tissues for aging research.

A Mouse Imaging facility for both functional and anatomical imaging.

MCCA SERVICES

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