The Aging and Phenotyping facility can accommodate at any given time 10,000 mice that are held in Individually Ventilated Cages (IVC racks) in several holding rooms. It has recently been decided to incorporate the MCCA Aging and Phenotyping Facility within the Central Animal Facility on the UMCG campus. The facility will be split into two sections, a double barrier part where life-span studies will be carried out and multiple mouse strains will be aged to a maximum of 24 months, There will be one procedure room in this section where simple experiments can be carried out. Experiments requiring interventions by the researchers will be carried out in a special section with a single barrier. All animals will be SOPF. Aged animals can also be transferred to other parts of the building, such as for instance for phenotyping of age-related parameters.
Currently, C57Bl/6J mice are being aged that can be requested by researchers for their studies. Upon request, any other mouse strain that researchers want to have aged under standardized conditions can be considered for housing at MCCA.
The Aging and Phenotyping facility can provide snap-frozen or paraffin-embedded tissues from young (4-8 months), middle aged (10-16 months), or old (20+ months) mice. A total of 33 tissues separately stored from each mouse. We have tissues of three strains: C57Bl/6J, Balb/c and DBA/2. The available tissues include tissues from:
- Digestive system
- Lymphoid system
- Thorax Urogenital system
- Endocrine organs
- Miscellaneous other tissues such as serum